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Barrett's Esophagus Diagnosis

Upper endoscopy with biopsy is the main diagnostic study. Endoscopy in a patient with Barrett's esophagus shows that the normal pale-white squamous mucosa of the lining of the esophagus has changed to a reddish (salmon color), columnar mucosa, similar to the lining of the stomach (see image below).

In patients with Barrett’s esophagus, a biopsy shows intestinal metaplasia, a change in the normal lining of the esophagus (squamous mucosa) to a lining similar to the that of the stomach (columnar mucosa), with the presence of goblet cells (see image below).