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Scleroderma

Scleroderma (or systemic sclerosis) is a rare disease of the connective tissues of the whole body. It can be localized to the skin or can affect multiple organs in the body including the gastrointestinal system. It starts with deposition of collagen in the vessels, muscles, skin, lungs, kidneys and the gastrointestinal system, affecting their normal function.

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By Michel Kafrouni, M.D

References

 1. Yarze JC, Varga J, Stampfl D, Castell DO, Jimenez SA.Esophageal function in systemic sclerosis: a prospective evaluation of motility and acid reflux in 36 patients. Am J Gastroenterol. 1993 Jun;88(6):870-6.
2. Ebert EC. Esophageal disease in scleroderma. J Clin Gastroenterol. 2006 Oct;40(9):769-75.
3. Kent MS, Luketich JD, Irshad K, Awais O, Alvelo-Rivera M, Churilla P, Fernando HC, Landreneau RJ. Comparison of surgical approaches to recalcitrant gastroesophageal reflux disease in the patient with scleroderma. Ann Thorac Surg. 2007 Nov; 84(5):1710-5.
4. Kafrouni MI. New Onset Dysphagia and Electrolyte Disturbance. Complicated Cases in GI. Chapter 52. Edited by Anthony Kalloo MD and Jonathan M. Buscaglia MD. Slack incorporated, 2009.