Twin-Twin Transfusion Syndrome (TTTS) – Experience Matters

The Fetal Center at Children’s Memorial Hermann Hospital utilizes the experience and expertise of the nationally recognized team of affiliated fetal surgeons to provide the highest level of care to patients. As a national referral program, The Fetal Center currently receives patient referrals from 38 states and continues to serve as a leader in fetal diagnosis, fetal intervention and comprehensive fetal care for unborn babies with abnormalities. Click here to learn more.

Below is an overview of The Fetal Center’s clinical outcomes data for the treatment of TTTS. We strive to provide our patients and community with the most up-to-date information on our patient outcomes. Our hope is that the below data serves as a helpful resource to you when making informed decisions regarding your care.

For more information about our data, contact The Fetal Center, at (832) 325-7288.

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Overall Summary

Since 2011, The Fetal Center has performed 668 cases of laser photocoagulation for the treatment of TTTS at Children’s Memorial Hermann Hospital. The data below reflects surgical volume from September 2011 – January 11, 2022 and represents 598 patients with known outcomes at 30 days post-delivery.

Overall, survival of both babies is seen in 76 percent of cases, with survival of one twin in 14 percent of cases.

Total Number of Laser Case Procedures: 668
Number of Laser Repeat Cases 9
Number of Deliveries 655
Number of Deliveries with Known 30-Day Outcome 598

 

TTTS 30-Day Post-Delivery Survival Rate by Gestational Age at Time of Fetal Intervention
Gestational Age at time of Procedure Total Pregnancies with Twin Survivors Pregnancies with One Twin Survivor Pregnancies with No Survivors
16 - 18 weeks 188 127 68% 35 19% 26 14%
19 - 21 weeks 232 186 80% 23 10% 23 10%
22 - 24 weeks 125 96 77% 18 14% 11 9%
25 - 27 weeks 48 39 81% 8 17% 1 2%
28 + weeks 5 5 100% 0 -- 0 --
SUMMARY 598 453 76% 84 14% 61 10%
 

30-Day Post-Delivery Survival Rate by TTTS Stage

The tables below reflect surgical volume from September 2011 – January 11, 2022 and represents data from 598 patients with known outcomes at 30 days post-delivery.

30-Day Post-Delivery Survival Rate by TTTS Stage

30-Day Post-Delivery Survival Rate by TTTS Stage
TTTS Stage Cases (percent of total cases*) Pregnancies with Twin Survivors Pregnancies with One Twin Survivor Pregnancies with No Survivors
Stage I 76 (13%) 67 (88%) 6 (8%) 3 (4%)
Stage II 170 (28%) 138 (81%) 15 (19%) 17 (10%)
Stage III 327 (55%) 228 (70%) 60 (18%) 39 (12%)
Stage IV 25 (4%) 19 (76%) 4 (16%) 2 (4%)
 

TTTS 30-Day Post-Delivery Survival Rate by Cervical Length

The Fetal Center is committed to a highly aggressive approach to the overall survival of all twin pregnancies, treating some of the rarest and high risk cases – including mothers with a cervical length of less than 1.5 cm, which increases a mother’s risk of spontaneous preterm birth by almost 50 percent, according to the American Journal of Obstetrics and Gynecology.

The below data reflects surgical volume from September 2011 – January 11, 2022. The data represents 598 patients with known outcomes at 30 days post-delivery, specifically highlighting outcomes based on mothers’ cervical length. As noted below, a cervical length of ≥ 1.5 cm was found in 95% of cases at The Fetal Center.

TTTS 30-Day Post-Delivery Survival Rate by Cervical Length

TTTS 30-Day Post-Delivery Survival Rate by Cervical Length
  Number of Cases* Pregnancies with Twin Survivors Pregnancies with One Twin Survivor Pregnancies with No Survivors
Number of cases with Cervical Length ≥ 1.5 cm 571 439 (77%) 82 (14%) 50 (9%)
Number of cases with Cervical Length ‹ 1.5 cm 27 13 (48%) 3 (11%) 11 (40%)
Total 598 452 (76%) 85 (14%) 61 (10%)

Note – Those with a cervical length of less than 1.5cm are at increased risk and should be seen by a physician as soon as possible. Please call The Fetal Center at (832) 325-7288.

 

The data represents patient volume from September 2011 through January 11, 2022.

We encourage you to reach out to other health care centers to request and review their outcomes data in order to utilize the information available when choosing your health care options.

Published January 2022.

Contact Us

When you contact The Fetal Center, you will be in touch with a dedicated coordinator who will walk you through the process step-by-step and help you to understand every aspect of your care.

The Fetal Center at Children's Memorial Hermann Hospital
UT Professional Building
6410 Fannin, Suite 210
Houston, Texas 77030

Phone: (832) 325-7288
Toll free: (888) 818-4818
Fax: (713) 383-1464
Email: thefetalcenter@memorialhermann.org

To contact The Fetal Center at Children's Memorial Hermann Hospital, please fill out the form below.

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You!

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If you need more immediate assistance, please call us during business hours at (832) 325-7288.

If you are experiencing a medical emergency, call 911 or go to the nearest emergency room.

Located within the Texas Medical Center, The Fetal Center is affiliated with McGovern Medical School at UTHealth Houston, UT Physicians and Children’s Memorial Hermann Hospital.

The Fetal Center Outcomes Data
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